It’s hard obviously to imagine a house which doesn’t have a door. I saw one one day, several years ago, in Lansing, Michigan. It had been built by Frank Lloyd Wright…[T]here appeared something like an open-work roof that was practically indissociable from the vegetation that had invaded it. In actual fact, it was already too late to know whether you were indoors or out…A dozen more or less similar houses were scattered through the surrounds of a private golf club. The course was entirely closed off. Guards…were on duty at the one entrance gate. –Georges Perec (1974)
Dosage and tolerance mark the thin line between palliative and poison.
The caffeine that perks up one patron in the coffeehouses of snowbound Minnesota can rocket another into rare tachycardia and cardiovascular collapse. It’s a chance many are willing to take. Even the jitters tell us we’re still alive in -40 wind chill. And look on the bright side, as one must here under the penalty of death, should a slurper keel over, a table in a popular joint is suddenly free for the rest of the day.
Farming Pathogens 